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    * Grapefruit *

    گریپ فروت

    (Wikipedia) - Grapefruit This article is about the fruit. For other uses, see Grapefruit (disambiguation). Grapefruit Scientific classification Binomial name
    Pink grapefruit, hybrid citrus.
    Kingdom: Plantae
    (unranked): Angiosperms
    (unranked): Eudicots
    (unranked): Rosids
    Order: Sapindales
    Family: Rutaceae
    Genus: Citrus
    Species: C. × paradisi
    Citrus × paradisi Macfad.

    The grapefruit (Citrus × paradisi) is a subtropical citrus tree known for its sour to semi-sweet fruit, an 18th-century hybrid first bred in Barbados. When found, it was named the "forbidden fruit"; and it has also been misidentified with the pomelo or shaddock (C. maxima), one of the parents of this hybrid, the other being sweet orange (C. × sinensis).

    • 1 Description
    • 2 History
      • 2.1 Ruby Red
      • 2.2 Star Ruby
    • 3 Varieties
    • 4 Production
    • 5 Colors and flavors
    • 6 Drug interactions
    • 7 Nutritional properties
    • 8 Grapefruit sweets
    • 9 Other uses
    • 10 See also
    • 11 References
    • 12 External links

    DescriptionGrapefruit growing in the grape-like clusters from which their name derives.

    The evergreen grapefruit trees usually grow to around 5–6 meters (16–20 ft) tall, although they can reach 13–15 m (43–49 ft). The leaves are glossy dark green, long (up to 15 centimeters (5.9 in)) and thin. It produces 5 cm (2 in) white four-petaled flowers. The fruit is yellow-orange skinned and generally an oblate spheroid in shape; it ranges in diameter from 10–15 cm (3.9–5.9 in). The flesh is segmented and acidic, varying in color depending on the cultivars, which include white, pink and red pulps of varying sweetness (generally, the redder varieties are sweeter). The 1929 US Ruby Red (of the Redblush variety) has the first grapefruit patent.

    History1750 Engraving of The Forbidden Fruit Tree by Georg Dionysius Ehret

    One ancestor of the grapefruit was the Jamaican sweet orange (Citrus sinensis), itself an ancient hybrid of Asian origin; the other was the Indonesian pomelo (C. maxima). One story of the fruit''s origins is that a certain "Captain Shaddock" brought pomelo seeds to Jamaica and bred the first fruit. However, it probably originated as a naturally occurring hybrid.

                             FORBIDDEN-FRUIT-TREE The Trunk, Leaves, and Flowers of this Tree, very much resemble those of the Orange-tree. The Fruit, when ripe, is something longer and larger than the largest Orange; and exceeds, in the Delicacy of its Taste, the Fruit of every Tree in this or any of our neighbouring Islands. It hath somewhat of the Taste of a Shaddock; but far exceeds that, as well as the best Orange, in its delicious Taste and Flavour.

    —Description from Hughes'' 1750 Natural History of Barbados.

    The hybrid fruit, then called "the forbidden fruit", was first documented in 1750 by a Welshman, Rev. Griffith Hughes, who described specimens from Barbados in The Natural History of Barbados. Currently, the grapefruit is said to be one of the "Seven Wonders of Barbados."

    The grapefruit was brought to Florida by Count Odet Philippe in 1823 in what is now known as Safety Harbor. Further crosses have produced the tangelo (1905), the Minneola tangelo (1931), and the oroblanco (1984).

    The grapefruit was known as the shaddock or shattuck until the 19th century. Its current name alludes to clusters of the fruit on the tree, which often appear similar to grapes. Botanically, it was not distinguished from the pomelo until the 1830s, when it was given the name Citrus paradisi. Its true origins were not determined until the 1940s. This led to the official name being altered to Citrus × paradisi, the "×" identifying its hybrid origin.

    Kimball Chase Atwood

    An early pioneer in the American citrus industry was Kimball Chase Atwood, a wealthy entrepreneur who founded the Atwood Grapefruit Co. in the late 19th century. The Atwood Grove became the largest grapefruit grove in the world, with a yearly output of 80,000 boxes of fruit. It was there that pink grapefruit was first discovered in 1906.

    Ruby Red

    The 1929 Ruby Red patent was associated with real commercial success, which came after the discovery of a red grapefruit growing on a pink variety. The Red grapefruit, starting with the Ruby Red, has even become a symbolic fruit of Texas, where white "inferior" grapefruit were eliminated and only red grapefruit were grown for decades. Using radiation to trigger mutations, new varieties were developed to retain the red tones which typically faded to pink, the Rio Red variety is the current (2007) Texas grapefruit with registered trademarks Rio Star and Ruby-Sweet, also sometimes promoted as "Reddest" and "Texas Choice". The Rio Red is a mutation bred variety which was developed by treatment of bud sticks with thermal neutrons. Its improved attributes of mutant variety are fruit and juice color, deeper red, and wide adaptation.

    Star Ruby

    The Star Ruby is the darkest of the red varieties. Developed from an irradiated Hudson grapefruit, it has found limited commercial success because it is more difficult to grow than other varieties.


    The varieties of Texas and Florida grapefruit include: Oro Blanco, Ruby Red, Pink, Thompson, White Marsh, Flame, Star Ruby, Duncan, and Pummelo HB.

    ProductionGrapefruit and pomelo output in 2005

    The United States is the top producer of grapefruit and pomelo followed by China and South Africa.

    Top ten grapefruit (inc. pomelos) producers — 2007 Country Production (metric tons) Footnote
     United States 1,580,000
     People''s Republic of China 547,000 F
     South Africa 430,000 F
     Mexico 390,000 F
     Syria 290,000 F
     Israel 245,000 *
     Turkey 181,923
     India 178,000 F
     Argentina 176,000 F
     Cuba 175,000 F
     World 5060000 A
    No symbol = official figure, P = official figure, F = FAO estimate, * = Unofficial/Semi-official/mirror data, C = Calculated figure A = Aggregate (may include official, semi-official or estimates);

    Source: Food And Agricultural Organization of United Nations: Economic And Social Department: The Statistical Division

    Colors and flavorsGrapefruit mercaptan

    Grapefruit comes in many varieties, determinable by color, which is caused by the pigmentation of the fruit in respect of its state of ripeness. The most popular varieties cultivated today are red, white, and pink hues, referring to the internal pulp color of the fruit. The family of flavors range from highly acidic and somewhat sour to sweet and tart. Grapefruit mercaptan, a sulfur-containing terpene, is one of the substances which has a strong influence on the taste and odor of grapefruit, compared with other citrus fruits.

    Drug interactions Main article: Grapefruit drug interactions

    Grapefruit can have a number of interactions with drugs, often increasing the effective potency of compounds. Researchers have identified 85 drugs with which grapefruit is known to have an adverse reaction. Grapefruit contains a number of polyphenolic compounds, including the flavanone naringin, alongside the two furanocoumarins bergamottin and dihydroxybergamottin. These inhibit the drug-metabolizing enzyme isoform CYP3A4 predominantly in the small intestine, but at higher doses also inhibit hepatic CYP3A4. It is via inhibition of this enzyme that grapefruit increases the effects of a variety of drugs by increasing their bioavailability. In particular grapefruit and bitter oranges are known to interact with statins.

    This white grapefruit is cushioned with a thick mesocarp layer

    When drugs are taken orally, they enter the gut lumen to be absorbed in the small intestine and sometimes, in the stomach. In order for drugs to be absorbed, they must pass through the epithelial cells that line the lumen wall before they can enter the hepatic portal circulation to be distributed systemically in blood circulation. Drugs are metabolized by drug-specific metabolizing enzymes in the epithelial cells. Metabolizing enzymes transform these drugs into metabolites. The primary purpose for drug metabolism is to detoxify, inactivate, solubilize and eliminate these drugs. As a result, the amount of the drug in its original form that reaches systemic circulation is reduced due to this first-pass metabolism.

    Grapefruit juice contains furanocoumarins. Furanocoumarins irreversibly inhibit a cytochrome P450 metabolizing enzyme called CYP3A4, as stated above. CYP3A4 is a metabolizing enzyme for almost 50% of drugs, and is found in the liver and small intestinal epithelial cells. As a result, many drugs are impacted by consumption of grapefruit juice. When the metabolizing enzyme is inhibited, less of the drug will be metabolized by it in the epithelial cells. A decrease in drug metabolism means more of the original form of the drug could pass unchanged to systemic blood circulation. An unexpected high dose of the drug in the blood could lead to fatal drug toxicity.

    The furanocoumarins found in grapefruit juice are natural chemicals. Thus, they are present in all forms of the fruit, including freshly squeezed juice, frozen concentrate, and whole fruit. All these forms of the grapefruit juice have the potential to limit the metabolizing activity of CYP3A4. One whole grapefruit, or a glass of 200 mL of grapefruit juice can cause drug overdose toxicity.

    According to a review done by the Canadian Medical Association, there is an increase in the number of potential drugs that can interact with grapefruit juice. From 2008 to 2012, the percentage of drugs that interact with grapefruit juice and cause serious harmful effects (gastrointestinal bleeding, nephrotoxicity) has increased from 17 to 43 percent.

    The interaction between grapefruit juice and other medication depends on the drug, and not the class of the drug. Drugs that interact with grapefruit juice share 3 common features: they are taken orally, normally only a small amount enters systemic blood circulation, and they are metabolized by CYP3A4.

    Inhibition of the CPA 3A4 enzyme is irreversible and lasts a significant period of time. It takes around 24 hours to regain 50% of the enzyme activity and it can take 72 hours for the enzyme to completely return to activity. For this reason, simply separating grapefruit consumption and medication taken daily does not avoid the interaction. For medications that interact due to inhibition of OATP (organic anion-transporting polypeptides), a relative short period of time is needed to avoid this interaction. A 4-hour interval between grapefruit consumption and the medication should suffice. For drugs recently sold on the market, drugs have information pages (monographs) that provide information on any potential interaction between a medication and grapefruit juice. Because there is a growing number of medications that are known to interact with grapefruit juice, patients should consult a pharmacist or physician before planning to take grapefruit juice with their medications.

    Grapefruit juice may be the first drug-interacting fruit juice documented, but apple and orange juices have been also implicated in interfering with etoposide, a chemotherapy drug, some beta blocker drugs used to treat high blood pressure, and cyclosporine, taken by transplant patients to prevent rejection of their new organs. Unlike other fruits, grapefruit contains a large amount of naringin, and it can take up to 72 hours before the effects of the naringin on the CYP3A4 enzyme are seen. This is problematic as a 4 oz portion of grapefruit contains enough naringin to inhibit the metabolism of substrates of CYP3A4.

    Nutritional propertiesPink grapefruit Grapefruit, raw, white, all areas Nutritional value per 100 g (3.5 oz) Energy Carbohydrates Sugars Dietary fiber FatProtein Vitamins Thiamine (B1) Riboflavin (B2) Niacin (B3) Pantothenic acid (B5) Vitamin B6 Folate (B9) Choline Vitamin C Vitamin E Trace metals Calcium Iron Magnesium Manganese Phosphorus Potassium Zinc Other constituents Water
    138 kJ (33 kcal)
    8.41 g
    7.31 g
    1.1 g
    0.10 g
    0.69 g
    (3%) 0.037 mg
    (2%) 0.020 mg
    (2%) 0.269 mg
    (6%) 0.283 mg
    (3%) 0.043 mg
    (3%) 10 μg
    (2%) 7.7 mg
    (40%) 33.3 mg
    (1%) 0.13 mg
    (1%) 12 mg
    (0%) 0.06 mg
    (3%) 9 mg
    (1%) 0.013 mg
    (1%) 8 mg
    (3%) 148 mg
    (1%) 0.07 mg
    90.48 g
    Link to USDA Database entry
    • Units
    • μg = micrograms • mg = milligrams
    • IU = International units
    Percentages are roughly approximated using US recommendations for adults. Source: USDA Nutrient Database

    Grapefruit is an excellent source of many nutrients and phytochemicals that contribute to a healthy diet. Grapefruit is a good source of vitamin C, contains the fiber pectin, and the pink and red hues contain the beneficial antioxidant lycopene. Studies have shown grapefruit helps lower cholesterol, and there is evidence that the seeds have antioxidant properties. Grapefruit forms a core part of the "grapefruit diet", the theory being that the fruit''s low glycemic index is able to help the body''s metabolism burn fat.

    Grapefruit seed extract (GSE) has been shown to have strong antimicrobial properties against fungi. It is also believed to have antimicrobial properties for bacteria, however there are no known studies that demonstrate its efficacy. Additionally, although GSE is promoted as a highly effective plant-based preservative by some natural personal care manufacturers, studies have shown that the apparent antimicrobial activity associated with GSE preparations is merely due to contamination with synthetic preservatives.

    There is a popular myth that grapefruits contain high amounts of spermidine, a simple polyamine that may be related to aging. The myth probably relies on the confusion between spermidine and putrescine. While citrus fruits show high amounts of putrescine, they contain very little spermidine.

    Grapefruit sweets

    In Costa Rica, especially in Atenas, grapefruit are often cooked to remove their sourness, rendering them as sweets; they are also stuffed with dulce de leche, resulting in a dessert called toronja rellena (stuffed grapefruit). In Haiti, grapefruit is used primarily for its juice (jus de Chadèque), but is also used to make jam (confiture de Chadèque).

    Other uses

    Grapefruit has also been investigated in cancer medicine pharmacodynamics. Its inhibiting effect on the metabolism of some drugs may allow smaller doses to be used, which can help to reduce costs.

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